Endocrine Abstracts

Bilateral ovariectomy (OVX) in female rats cause neurodegeneration in the nervous system of rodents and imitates systemic disorders in postmenopausal women’s organism. Synaptic modulation by estrogen is essential to understand the molecular mechanisms of estrogen replacement therapy. The aim of present work was to determine the action of Sinestrol on rats’ hippocampal synaptic transmission, plasticity and cell survival in condition of bilateral OVX. Electrophysiologi...